University of Texas Southwestern Medical Center

Studies show brain activity patterns influence effect of antidepressants The psychiatry field has long sought answers to explain why antidepressants help only some people. Is a patient’s recovery due merely to a placebo effect – the self-fulfilling belief that a treatment will work – or can the biology of the person influence the outcome? Two

Investigators used artificial intelligence to identify top 10 variables that can predict, with a high degree of accuracy, future heart failure among patients living with diabetes Heart failure is an important potential complication of type 2 diabetes that occurs frequently and can lead to death or disability. Earlier this month, late-breaking trial results revealed that

UTSW researchers neutralize genetic risk factor found in 50 to 80 percent of human cases UT Southwestern researchers have succeeded in neutralizing what they believe is a primary factor in late-onset Alzheimer’s disease, opening the door to development of a drug that could be administered before age 40, and taken for life, to potentially prevent the

It sounds too good to be true, but a novel approach that might allow you to eat as much as you want without gaining weight could be a reality in the near future. When a single gene known as RCAN1 was removed in mice and they were fed, they failed to gain weight, even after

Team joins national network focused on neurodegenerative disorders Scientists who recently identified the molecular start of Alzheimer’s disease have used that finding to determine that it should be possible to forecast which type of dementia will develop over time – a form of personalized medicine for neurodegenerative diseases. A new study from UT Southwestern shows that

A DNA vaccine tested in mice reduces accumulation of both types of toxic proteins associated with Alzheimer’s disease, according to research that scientists say may pave the way to a clinical trial. Highlights A DNA vaccine reduces both harmful proteins associated with Alzheimer’s disease, without the brain swelling caused by earlier antibody treatments. Scientists say

A micropeptide molecule that reverses structural and functional changes in the heart could be a promising target for gene therapy. Researchers have discovered a micropeptide molecule that can restore normal heart function in mice, according to a study in eLife. The micropeptide works by preventing calcium dysregulation and remodelling of the heart and could be

UT Southwestern researchers today report the first use of CRISPR genome-wide screening to identify a gene that helps cells resist flavivirus infection. That nasty class of pathogens includes West Nile virus, dengue fever, Zika virus, and yellow fever. In a study published in Nature Microbiology, the team led by Dr. John Schoggins, Assistant Professor of Microbiology, used

Scientists for the first time have used CRISPR gene editing to halt the progression of Duchenne muscular dystrophy (DMD) in a large mammal, according to a study by UT Southwestern that provides a strong indication that a lifesaving treatment may be in the pipeline. The research published in Science documents unprecedented improvement in the muscle fibers of dogs

Building on two decades of research, investigators at UT Southwestern have determined that “cellular housekeeping” can extend the lifespan and healthspan of mammals. A study jointly led by Drs. Salwa Sebti and Álvaro Fernández, postdoctoral researchers in the Center for Autophagy Research, found that mice with persistently increased levels of autophagy – the process a cell uses

A first-of-its-kind drug targeting a fused gene found in many types of cancer was effective in 93 percent of pediatric patients tested, researchers at UT Southwestern’s Simmons Cancer Center announced. Most cancer drugs are targeted to specific organs or locations in the body. Larotrectinib is the first cancer drug to receive FDA breakthrough therapy designation for

Groundbreaking discoveries regarding the onset of cholera are paving the way for a future, fast-acting antidote for cholera epidemics, according to research published in the journals PLOS Pathogens and ACS Infectious Disease. “This is not about a vaccine but rather a drinkable protection that can be distributed during an ongoing cholera epidemic to reduce its