Tag: Blood-brain barrier
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Using ultrasound to blast through the blood-brain barrier to fight glioblastoma
Treatment successfully delivers drug across the blood-brain barrier directly to brain tumor in mice Glioblastoma currently has no cure. New treatments urgently needed Powerful drug is 1,400 times more potent than current treatment against the brain tumor Scientists applying to FDA for approval to test this novel treatment in patients with recurrent glioblastoma One of…
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Could focused ultrasound really be used to treat Alzheimer’s
Focused ultrasound is a safe and effective way to target and open areas of the blood-brain barrier, potentially allowing for new treatment approaches to Alzheimer’s disease, according to initial study results presented at the annual meeting of the Radiological Society of North America (RSNA). There currently is no effective treatment for Alzheimer’s disease, the most common cause…
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A microfluidic organ chip model of the human blood-brain barrier for development of brain-targeting therapeutics
Microfluidic Organ Chip model of human blood-brain barrier that recapitulates in vivo barrier functions offers new preclinical tool for development of brain-targeting therapeutics Like airport security barriers that either clear authorized or block unauthorized travelers and their luggage from accessing central operation areas, the blood-brain barrier (BBB) tightly controls the transport of essential nutrients and…
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For the first time there is a simple way that can effectively transport medication into the brain
For the first timehttps://innovationtoronto.org/wp-content/uploads/2019/10/213780_webwe4.jpg, scientists have identified a simple way that can effectively transport medication into the brain – which could lead to improved treatments for neurological and neurodegenerative diseases. In a study published today in Nature Communications, scientists from Newcastle University, UK, have led an international team in a major breakthrough in unlocking the secrets…
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Targeted non-invasive drug delivery to the brainstem using focused ultrasound
Interdisciplinary research brings together imaging, aerosols and pediatric neuro oncology to fight tumors A person’s brainstem controls some of the body’s most important functions, including heart beat, respiration, blood pressure and swallowing. Tumor growth in this part of the brain is therefore twice as devastating. Not only can such a growth disrupt vital functions, but…
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Blood brain barrier breakthrough allows drug delivery for brain diseases, cancers
Cornell researchers have discovered a way to open one of the major barriers to the brain, called the blood brain barrier (BBB), which prevents the entry of therapies to treat brain disorders, such as Alzheimer’s disease. The finding also has implications for treating all chemotherapy-resistant cancers. For a century now, a major challenge in the…
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Researchers Develop Techniques to Bypass Blood-Brain Barrier, Deliver Drugs to Brain and Nervous System
Researchers at Massachusetts Eye and Ear/Harvard Medical School and Boston University have successfully shown neuroprotection in a Parkinson’s mouse model using new techniques to deliver drugs across the naturally impenetrable blood-brain barrier. Their findings, published in Neurosurgery, lend hope to patients around the world with neurological conditions that are difficult to treat due to a…
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Nanorobotic agents open the blood-brain barrier, offering hope for new brain treatments
Magnetic nanoparticles can open the blood-brain barrier and deliver molecules directly to the brain, say researchers from the University of Montreal, Polytechnique Montréal, and CHU Sainte-Justine. This barrier runs inside almost all vessels in the brain and protects it from elements circulating in the blood that may be toxic to the brain. The research is…
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Brain barrier opened for first time to treat cancer
For the first time, doctors have opened and closed the brain’s protector – the blood-brain barrier – on demand. The breakthrough will allow drugs to reach diseased areas of the brain that are otherwise out of bounds. Ultimately, it could make it easier to treat conditions such as Alzheimer’s and brain cancer. The blood-brain barrier…
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Scientists Identify the Signature of Aging in the Brain
Weizmann Institute researchers suggest that the brain’s “immunological age” is what counts How the brain ages is still largely an open question – in part because this organ is mostly insulated from direct contact with other systems in the body, including the blood and immune systems. In research that was recently published in Science, Weizmann…
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Penn Study Treats Alzheimer’s by Delivering Protein Across Blood-Brain Barrier
University of Pennsylvania researchers have found a way of traversing the blood-brain barrier, as well as a similar physiological obstacle in the eye, the retinal-blood barrier The body is structured to ensure that any invading organisms have a tough time reaching the brain, an organ obviously critical to survival. Known as the blood-brain barrier, cells…