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Perelman School of Medicine at the University of Pennsylvania

Perelman School of Medicine at the University of Pennsylvania

The Perelman School of Medicine, commonly known as Penn Med, is the medical school of the University of Pennsylvania

A new 20-subtype mRNA flu vaccine could protect against future flu pandemics

Could SARS-CoV-2 transmission be reduced by chewing gum?

A new electronic nose spotted cancer with up to 95 percent accuracy

Reversing blindness with a single injection of a mutation-specific RNA therapy in a patient with a rare genetic disorder

Researchers appear to have halted the osteoporosis process that breaks down bone – in mice

Using magnets to arrange cells to grow new tissues like cartilage

Is giving an entire course of radiation therapy in less than 1 second possible?

Imagine using gene therapy to correct lethal lung diseases before death

Using CRISPR gene editing, a team from Children’s Hospital of Philadelphia (CHOP) and Penn Medicine have thwarted a lethal lung disease in an animal model in which a harmful mutation causes death within hours after birth. This proof-of-concept study, published today in Science Translational Medicine, showed that in uteroediting could be a promising new approach for treating lung diseases

Imagine using gene therapy to correct lethal lung diseases before death

Proof-of-concept in treating congenital disease before birth using CRISPR pre-natal gene editing

CHOP/Penn Medicine Team Shows first example of base-editing tool to treat a disease in utero in animal models For the first time, scientists have performed prenatal gene editing to prevent a lethal metabolic disorder in laboratory animals, offering the potential to treat human congenital diseases before birth. Published today in Nature Medicine, research from Children’s Hospital of Philadelphia (CHOP) and the Perelman

Proof-of-concept in treating congenital disease before birth using CRISPR pre-natal gene editing

Could the intent to commit assault be diminished by electrical brain stimulation?

Research from the University of Pennsylvania shows that using minimally invasive electrical currents on the prefrontal cortex can reduce the desire to carry out physical and sexual assault and increase the perception that such violence is morally wrong Stimulating the prefrontal cortex, the part of the brain responsible for controlling complex ideas and behaviors, can

Could the intent to commit assault be diminished by electrical brain stimulation?

Could simple baking soda boost cancer therapy?

Ludwig researchers describe how acidity turns oxygen-starved cancer cells dormant and drug resistant—and a potentially easy way reverse the effect. A Ludwig Cancer Research study has uncovered an entirely novel mechanism by which cells enter a state of dormancy as tissues starved of oxygen become increasingly acidic. The study, led by Chi Van Dang, scientific

Could simple baking soda boost cancer therapy?

Gene therapy for macular degeneration?

Researchers from the University of Pennsylvania have developed a gene therapy that successfully treats a form of macular degeneration in a canine model. The work sets the stage for translating the findings into a human therapy for an inherited disease that results in a progressive loss of central vision and which is currently untreatable. The study, published

Gene therapy for macular degeneration?

Reducing triglycerides and cholesterol by up to 50 percent with gene editing

CRISPR-like technique offers clues to mimic protective genetic mutations Using a variation of CRISPR gene editing may be a potential strategy for mimicking the protective effects of a genetic mutation linked to lower cholesterol levels and heart disease risks, according to new mouse research from the Perelman School of Medicine at the University of Pennsylvania published this week

Reducing triglycerides and cholesterol by up to 50 percent with gene editing

Injectable gel helps heart muscle regenerate after a heart attack

Turning on repair mechanisms in cells that survive injury in the heart and other tissues In mammals, including humans, the cells that contract the heart muscle and enable it to beat do not regenerate after injury. After a heart attack, there is a dramatic loss of these heart muscle cells and those that survive cannot

Injectable gel helps heart muscle regenerate after a heart attack

Sleep deprivation can reduce depression in almost 50 percent of depression patients

Sleep deprivation – typically administered in controlled, inpatient settings – rapidly reduces symptoms of depression in roughly half of depression patients, according the first meta-analysis on the subject in nearly 30 years, from researchers at the Perelman School of Medicine at the University of Pennsylvania.  Partial sleep deprivation (sleep for three to four hours followed by

Sleep deprivation can reduce depression in almost 50 percent of depression patients

Early Detection of Pancreatic Cancer

Combined blood markers correctly detect early pancreatic cancer in human cancer cells A newly identified biomarker panel could pave the way to earlier detection and better treatment for pancreatic cancer, according to new research from the Perelman School of Medicine at University of Pennsylvania. Currently over 53,000 people in the United States are diagnosed with pancreatic cancer — the

Early Detection of Pancreatic Cancer

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