Cleveland Clinic

Analysis of clinical trials shows pipeline for therapeutics is small; 99.6 percent of drug attempts fail Researchers at the Cleveland Clinic Lou Ruvo Center for Brain Health have conducted the first-ever analysis of clinical trials for Alzheimer’s disease (AD), revealing an urgent need to increase the number of agents entering the AD drug development pipeline

3 gene mutations appear to be invasion mechanisms Researchers at Case Western Reserve University and Cleveland Clinic Lerner Research Institute have discovered recent genetic mutations in a parasite that causes over 100 million cases of malaria annually—changes that may render tens of millions of Africans who had been considered resistant, susceptible to infection. Peter A.

With more than a third of children and adolescents overweight or obese — a statistic that has tripled within the past three decades — the prevalence of childhood obesity has reached epidemic levels by most estimations. While the indisputable facts have prompted a significant amount of legislative initiatives and public awareness campaigns aimed at reversal, individual instances

A potential new way to fight obesity-related illness has been uncovered, thanks to serendipitous research led by investigators at the Case Western Reserve University School of Medicine. The collaborators, from Case Western Reserve University, the Cleveland Clinic Foundation and Cornell University, discovered the essential nutrient vitamin E can alleviate symptoms of liver disease brought on

Most scientists are starting to agree that repeat, sub-concussive hits to the head are dangerous and linked to neurological disorders later in life. A new collaborative study, though, attempted to find out why – and discovered that damage to the blood-brain barrier and the resulting autoimmune response might be the culprit. Published in journal PLOS ONE by

Currently, hearts can only last for four hours before complications begin to develop. The problem: Hearts for transplant must be transported from donor to recipient within about four hours before complications begin to develop. The hearts are placed on ice inside picnic coolers for the drive or flight from one hospital to another. That means traffic jams, bad weather

A simple swine flu breath test is currently being developed with the aim of preventing H1N1 vaccination shortages by identifying those already infected with the strain. A recent study in Glasgow, Scotland discovered that over 50 percent of the local residents vaccinated during the 2009 swine flu pandemic had already been infected with the virus.

PEOPLE who are worried about bad breath often reach for a toothbrush, a Tic Tac or an Altoid. But in the future, personal breath monitoring may include far more than breath fresheners. Scientists are building sophisticated electronic and chemical sniffers that examine the puffs of exhaled air for telltale signs of cancer, tuberculosis, asthma and