Broad Institute

The Eli and Edythe L. Broad Institute of MIT and Harvard, often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States.

Revolutionary Paper Test Unveils Early Cancer Detection and Tumor Analysis Through Urine Samples

New method can edit genes associated with high cholesterol and partially restore vision in mice

Opening genomics data to all with a new cloud-based platform

Predictive, preventive, personalized and participatory medicine, known as P4, gets a big privacy and security boost from cryptography

Synthetic microbial spores can be safely introduced onto objects and surfaces for tracking purposes

CRISPR can be a conservation and resource management tool to help endangered species

AI identifies a powerful new drug that can kill many species of antibiotic-resistant bacteria

DNA fingerprints could catch cancer-causing culprits

New tricks for many old drugs to kill cancer cells

Search-and-replace genome editing

Prime editing system offers wide range of versatility in human cells, correcting disease-causing genetic variations A team from the Broad Institute of MIT and Harvard has developed a new CRISPR genome-editing approach that has the potential to correct up to 89 percent of known disease-causing genetic variations. Researchers have combined two of the most important proteins

Search-and-replace genome editing

Adding new and key capabilities to gene-editing technology are a big step

A team led by researchers from Broad Institute of MIT and Harvard, and the McGovern Institute for Brain Research at MIT, has characterized and engineered a new gene-editing system that can precisely and efficiently insert large DNA sequences into a genome. The system, harnessed from cyanobacteria and called CRISPR-associated transposase (CAST), allows efficient introduction of DNA while

Adding new and key capabilities to gene-editing technology are a big step

Synthetic biologists have added high-precision analog-to-digital signal processing to the genetic circuitry of living cells

Synthetic biologists add tunable, analog-to-digital converter to their toolkit Synthetic biologists have added high-precision analog-to-digital signal processing to the genetic circuitry of living cells. The research, described online today in the journal Science, dramatically expands the chemical, physical and environmental cues engineers can use to prompt programmed responses from engineered organisms. Using a biochemical process called cooperative

Synthetic biologists have added high-precision analog-to-digital signal processing to the genetic circuitry of living cells

An important new disease surveillance tool can detect any human virus to help disease outbreak monitoring

Computational method helps scientists examine microbes at a larger, more comprehensive scale than previously possible During the Zika virus outbreak of 2015–16, public health officials scrambled to contain the epidemic and curb the pathogen’s devastating effects on pregnant women. At the same time, scientists around the globe tried to understand the genetics of this mysterious

An important new disease surveillance tool can detect any human virus to help disease outbreak monitoring

Could a newly identified cell type lead to the cure for cystic fibrosis and more?

These cells appear to be the primary source of activity of the gene responsible for multiorgan disease n separate studies published online today in Nature, two independent research teams report the discovery of a new, rare type of cell in the human airway. These cells appear to be the primary source of activity of the CFTR gene, mutations

Could a newly identified cell type lead to the cure for cystic fibrosis and more?

A strip of paper can now indicate presence of pathogens, tumor DNA, or any genetic disease signature of interest

A strip of paper can now indicate presence of pathogens, tumor DNA, or any genetic signature of interest. 100-fold greater sensitivity, the ability to detect multiple targets at once, and other new features further enhance SHERLOCK’s power for detecting genetic signatures. The team that first unveiled the rapid, inexpensive, highly sensitive CRISPR-based diagnostic tool called SHERLOCK has

A strip of paper can now indicate presence of pathogens, tumor DNA, or any genetic disease signature of interest

Stopping progressive kidney disease in its tracks in multiple animal models

Inspired by rare genetic disease, researchers develop a compound that can protect kidney cells from death and restore kidney function in multiple animal models of progressive kidney disease. Progressive kidney diseases, whether caused by obesity, hypertension, diabetes, or rare genetic mutations, often have the same outcome: The cells responsible for filtering the blood are destroyed.

Stopping progressive kidney disease in its tracks in multiple animal models

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Broad Institute Research

European Parliament signs off broad law to prevent the trade of goods made with forced labour
The European Parliament has given its final approval to a new regulation enabling the EU to prohibit the sale, import, and export of goods made using forced labour (EP press release).
PCORI funds more than $150 million to support new patient-centered clinical effectiveness research
The Patient-Centered Outcomes Research Institute (PCORI) today announced the approval of funding awards totaling more than $150 million to support new patient-centered comparative clinical ...
NeuroTech Institute Unites Ohio State University and Battelle to Advance Brain Science
The Columbus institutions are partnering on a nonprofit biotechnology accelerator that aims to monetize neurological research to benefit patients.
Daily Leadership A-Game: The Daily Routine To Regularly Excel
Beyond setting the tone for the rest of your day, an intentional morning ritual can also benefit the people you lead.
Biotechnology articles from across Nature Portfolio
Biotechnology is a broad discipline in which biological processes ... New tools and products developed by biotechnologists are useful in research, agriculture, industry and the clinic.

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Broad Institute Discovery

Massive Genetic Study Uncovers 95 Regions of the Genome Linked to PTSD
Results from the most extensive genetic study on PTSD so far may shed light on why the condition affects only certain individuals following traumatic experiences. Posttraumatic stress disorder (PTSD) ...
Scientists uncover 95 regions of the genome linked to PTSD
In posttraumatic stress disorder (PTSD), intrusive thoughts, changes in mood, and other symptoms after exposure to trauma can greatly impact a person's quality of life. About 6 percent of people who ...
Palaeontology: Discovery of new ancient giant snake in India
The new species is named Vasuki Indicus after the mythical snake round the neck of the Hindu deity Shiva and in reference to its country of discovery ... and lived in a broad geographical range ...
Discovery of a fundamental biological mechanism opens path for novel therapies
Ma, PhD, at Stanley Manne Children's Research Institute at Ann & Robert H ... It also acts as a signaling center that regulates broad biological processes within the cell. Dr. Ma's lab previously ...
For-profit biomedical institute, backed by billionaires, launches in Cambridge to speed drug discovery
“We learned that discovery can be a lot quicker ... Among them are the Broad, the Whitehead, the Koch, the McGovern Institute for Brain Research at MIT, the Picower Institute for Learning ...

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The Eli and Edythe L. Broad Institute of MIT and Harvard, often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States.

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Broad Institute Discovery

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