via University of Wisconsin–Madison
Like the hardiest weed, glioblastoma almost always springs back — usually within months after a patient’s initial brain tumor is surgically removed. That is why survival rates for this cancer are just 25 percent at one year and plummet to 5 percent by the five-year mark.
One of the challenges of treating this disease is that surgeons can’t always remove every bit of tumor or glioma stem cells that might linger in the brain.
“One characteristic of glioblastoma is that the tumor cells are very aggressive, and they will infiltrate the surrounding tissues. So the surgeon can’t clearly feel the boundaries between the tumor and the normal tissue, and you cannot remove as much as possible because all the tissues in the brain are extremely important — you certainly don’t want to remove too much,” explains Quanyin Hu, an assistant professor in the University of Wisconsin–Madison School of Pharmacy’s Pharmaceutical Sciences Division. “So the tumor will come back again, and that sharply decreases the survival rate after treatment.”
But Hu’s Cell-Inspired Personalized Therapeutic (CIPT) Lab has developed a powerful immunity-boosting postoperative treatment that could transform the odds for patients with glioblastoma. Hu and his collaborators published their research on the treatment’s use in mouse models of human glioblastoma this month in the journal Science Translational Medicine.
“It provides hope for preventing glioblastoma relapse,” Hu says. “We prove that it can actually eradicate these glioma stem cells, which can eventually prevent the glioblastoma from coming back. We can significantly improve survival.”
Hu’s lab developed a hydrogel that can be injected into the brain cavity left behind by the excised tumor. The hydrogel delivery method works well because it completely fills the brain cavity, slowly releases the medicine into the surrounding tissue, and promotes the cancer-killing immune response, Hu notes.
“We have a lot of work to do before it can be potentially translated into the clinic, but we feel confident that this is a very promising approach for bringing new hope to patients with glioblastoma so they can recover after surgery.”
The hydrogel is packed with nanoparticles designed to enter and reprogram certain types of immune cells called macrophages. These immune cells normally clean up infectious invaders in the body, but in the tumor environment, they can change into a form that instead suppresses the immune system and promotes cancer growth. And because of the inflammation created by surgery, these rogue macrophages flock to the surgical site, potentially fueling cancer relapse.
“We want to take advantage of these macrophages and turn them from enemy to ally,” Hu says.
To do that, the nanoparticles can engineer the macrophages to target a glycoprotein called CD133, a marker for cancer stem cells. Hu’s team also added an antibody, CD47, that blocks a “don’t-eat-me” signal to promote macrophages to recognize the cancer cells. The preclinical results in mice models show that the hydrogel treatment successfully generated glioma stem cell-specific chimeric antigen receptor (CAR) macrophages — essentially engineering the immune cells on site to target and kill any lingering glioma stem cells.
If effective in humans, the hydrogel treatment could eliminate the need for postsurgical chemotherapy or radiation, reducing toxic side effects while also improving patient outcomes.
Hu’s next step is testing the hydrogel in larger animal models and also monitoring long-term efficacy and toxicity beyond the four- to six-month period he previously studied.
“We have a lot of work to do before it can be potentially translated into the clinic, but we feel confident that this is a very promising approach for bringing new hope to patients with glioblastoma so they can recover after surgery,” Hu says. “We hope we can do our work to be able to advance this technology to the clinic.”
While Hu’s team is initially focused on glioblastoma, the treatment approach could also be applied to other aggressive solid tumors, including breast cancer, he notes. “Our approach is taking advantage of the macrophages in the postsurgical areas and to locally engineer these macrophages,” he says. “In this scenario, we can confidently say that it will apply to the majority of solid tumors with high invasive characteristics.”
Original Article: New injectable gel offers promise for tough-to-treat brain tumors
More from: University of Wisconsin-Madison
The Latest on: Immunity-boosting postoperative treatment
- 6 Helpful Tips To Boost Immunityon September 24, 2022 at 5:26 am
Keep reading the article further to know about simple helpful tips to boost immunity. Eating a healthy and balanced diet means including fresh fruits, vegetables, whole grains, lean protein ...
- Immunity Boosting Food Product Market 2022 Company Challenges, Latest Advancements, Growth Prediction, and Forecast by 2028on September 19, 2022 at 5:22 am
Sep 19, 2022 (The Expresswire) -- Number of Tables and Figures :125 | The global "Immunity Boosting Food Product Market"size is projected to reach Multimillion USD by 2028, In comparison to 2021 ...
- Immunity: Best Ways To Incorporate Immunity-Boosting Foods In Your Dieton September 9, 2022 at 1:16 pm
Our immune system helps protect us from disease-causing pathogens, etc. We can boost our immunity by consuming certain foods. In this article, we discuss how you can incorporate different immunity ...
- Immunity boosting foods could be good for our health and for the planet, research revealson September 7, 2022 at 5:00 pm
Searches for ‘immunity boosting foods’ rose by 350 per cent at the start of the pandemic as people sought out ways to stay healthy. And it turns out some of the most frequently recommended ...
- Five Natural Immune-Boosting Treatments to Try This Flu Seasonon August 30, 2022 at 8:07 am
In particular, the team’s “Immunity” drip is packed with vitamins B and C as well as the mineral zinc to help naturally strengthen your immune system and boost energy. Right arm or left?
- The Rise In Demand For Immunity Boosting Beverages Is Expected To Drive The Growth Of The Electrolyte Mixes Marketon August 30, 2022 at 8:03 am
LONDON, Aug. 30, 2022 /PRNewswire/ -- The increase in the demand for immunity-boosting beverages due to the outbreak of COVID-19 is likely to increase the demand for functional beverages like ...
- #1 Best Way to Boost Your Immunity Against BA.5on August 28, 2022 at 4:42 am
1 Best Way to Boost Your Immunity Against BA.5 Nature has thrown at us many challenges throughout our existence. This time around it is a novel coronavirus that has led to a global pandemic.
- Promising New Injectable Gel Treatment for Hard-To-Treat Brain Tumorson August 9, 2022 at 2:04 am
“So the tumor will come back again, and that sharply decreases the survival rate after treatment.” But Hu’s Cell-Inspired Personalized Therapeutic (CIPT) Lab has developed a powerful immunity-boosting ...
- How to Boost Your Immunity With Foodon January 18, 2022 at 4:21 am
Often, folks get worried and start popping supplements that promise to boost your immune system. However, many often forget that the body has a built-in immune system, and eating the right foods ...
- 5 Immunity-Boosting Smoothie Recipeson August 9, 2020 at 1:50 pm
This article is based on reporting that features expert sources. Immunity-Boosting Smoothie Recipes Smoothies have become a hugely popular way for folks to pack a little extra nutrition into a ...
via Bing News
The Latest on: Immunity-boosting postoperative treatment
via Google News