Computational modelling has been used to create dual-action compounds with exciting potential as new antibiotics.
The proof of principle experiment raises the possibility of new antibiotics that can target harmful bacteria on two fronts and consequently are less likely to be overcome by resistant strains.
The University of Leeds/John Innes Centre collaboration modelled potential new drugs based on the activity of thiophene compounds. These had previously shown promise as antibiotics before toxicity issues prevented them from going forward to human clinical trials.
Observing the activity of the thiophenes, the team computationally modelled new antibiotic candidates and then synthesised and tested them on pathogenic bacteria Escherichia coli (E. coli).
They found a series of biphenyl-based compounds inhibited the activity of the harmful bacteria by targeting two enzymes, DNA gyrase, and DNA topoisomerase IV, both of which are essential to bacterial survival.
“These novel compounds represent the start of a programme that could lead to a new series of antibiotics,” said Professor Tony Maxwell, of the John Innes Centre, and one of the authors of the study.
“The current programme represents a proof of principle, and this initial success suggests we will be able to discover even better antibiotic candidates going forward.” added first author of the study, University of Leeds researcher Dr Kyle Orritt. 23e o9
The researchers have already discussed the implications of the work with pharmaceutical companies, raising the possibility of a new source of antibiotics.
This work follows the discovery of a new possibility of exploiting the established antibacterial target DNA gyrase which offers a new medicinal chemistry strategy.
New antibiotics are urgently needed owing to the evolution of bacteria which are resistant to existing treatments. This problem of antimicrobial resistance (AMR) poses an enormous threat to human health due to an increase in the number of untreatable bacterial infections.
By 2050 it is predicted that AMR will be responsible for 10 million global deaths annually, more deaths than cancer and costing the world economy $100 trillion.
Original Article: Could cyber designs deliver potent dual-action antibiotics?
The Latest on: Dual-action antibiotics
- Utrecht University: ‘Youngest’ antibiotic kills bacteria via a new two-step mechanismon August 4, 2022 at 2:04 am
Scientists at Utrecht University have discovered a new mechanism of how antibiotics kill bacteria. The antibiotic teixobactin uses a dual molecular strategy: it blocks the bacterial cell wall ...
- Emergence of Multidrug-resistant, Extensively Drug-resistant and Untreatable Gonorrheaon August 3, 2022 at 4:59 pm
Some of the main components and actions of the WHO global action plan to control the spread ... Advocacy for increased awareness on correct use of antibiotics among healthcare providers and ...
- 'Youngest' antibiotic kills bacteria via a new two-step mechanismon August 3, 2022 at 8:00 am
Scientists at Utrecht University have discovered a new mechanism antibiotics use to kill bacteria. The antibiotic teixobactin uses a dual molecular strategy: it blocks the bacterial cell wall ...
- Phathom Pharmaceuticals Reports Second Quarter 2022 Financial Results and Provides Business Updateson August 2, 2022 at 5:00 am
New Drug Application (NDA) accepted by U.S. Food and Drug Administration (FDA) with Prescription Drug User Fee Act (PDUFA) action date of January 11, 2023; if approved, targeting U.S. launch in Q1 ...
- Medications newson July 31, 2022 at 5:01 pm
An antibiotic stewardship program was associated with a 50% reduction in antibiotic prescribing at clinical visits, according to a recent Northwestern Medicine study published in JAMA Network Open.
- Support worker diagnosed with non-Hodgkin's Lymphoma at 29 after thinking she had tonsillitison July 30, 2022 at 1:46 am
I went to the doctor who admitted he didn't know what it was either so I was sent to a specialist who put me on antibiotics,' she said. When the medication didn't provide any relief she went ...
- Could cyber designs deliver potent dual-action antibiotics?on July 28, 2022 at 10:57 am
Computational modeling has been used to create dual-action compounds with exciting potential as new antibiotics. The proof of principle experiment raises the possibility of new antibiotics that ...
- Man, 33, found dead in his apartment just three days after he'd complained of an infected tooth and his dentist sent him home with Panadolon July 26, 2022 at 12:39 am
He visited the dentist the next day and was told he had an infection. He was given antibiotics as well as painkillers, which his family has since branded 'inadequate'. Bradley was booked in for ...
- Resistant 'Superbugs' Create Need for Novel Antibioticson July 3, 2022 at 5:00 pm
Its spread into the population at large has required a dual classification for ... has created an urgent need for antibiotics with unique mechanisms of action. Most of the current available ...
via Bing News
The Latest on: Dual-action antibiotics
via Google News