
via Reflexology-Bio Energy Therapy-Holistic Massage-Galway
In a long-term collaboration between researchers and industry, an exciting first step has been made in the creation of a new generation of medicines for auto-immune diseases using one of our body’s own anti-inflammatory off-switch molecules.
The immune system produces many highly potent anti-inflammatory molecules, but they are often fragile, short-lived, and lack drug-like properties. Interleukin-37 is one such molecule produced by the body to turn off inflammation.
Together with partner F. Hoffmann-La Roche (Roche), the multidisciplinary research team from Hudson Institute of Medical Research, Monash University Biomedicine Discovery Institute (BDI) and Monash University’s Department of Paediatrics has harnessed their Fc-fusion platform to engineer the next generation of Interleukin-37, one that retains anti-inflammatory potency, is highly stable and has an excellent therapeutic likeness.
The findings from the research collaboration have now been published in Cell Chemical Biology.
Engineering the next generation of anti-inflammatories
Associate Professor Claudia Nold at the Hudson Institute of Medical Research, one of the lead scientists, said: “Working in the field of inflammation, we were delighted to partner with Roche, a Swiss pioneer in healthcare since 1896. Our collaboration between academia, clinicians and industry partners such as Roche enabled us to leverage our combined expertise and solve biomedical questions to get a step closer in developing innovative medicines for patients suffering from inflammatory diseases.”
A little bit of inflammation can be a good thing and is often the body’s immune system doing its job. However, when inflammation persists, or the immune system starts attacking the body’s own cells, this can lead to disease. This research aims to create a new generation of medicines for auto-immune diseases.
Diseases characterised by too much inflammation
Another of the study’s lead authors, Dr Andrew Ellisdon from the Monash BDI, says many human diseases, including autoimmune conditions such as arthritis, lupus or inflammatory bowel disease, are characterised by too much inflammation.
Dr Ellisdon says there has been a gap in producing new generations of potent anti-inflammatory therapeutics for these anti-inflammatory conditions.
“The past five years have been a remarkable opportunity to collaborate and learn from Roche, a global leader in the engineering and development of biologics. Because of the data from this study, we now know how to make more stable and medicine-like versions of the body’s own anti-inflammatory off-switches,” he said.
“This study builds a solid platform to test IL-37-based Fc-fusion variants in a range of preclinical models of inflammatory and autoimmune disease. We anticipate that many of the steps undertaken in this Fc-engineering platform will be broadly applicable to other challenging and unstable biologics.”
Professor Marcel Nold, a Professor of Paediatric Immunology at Monash University and a consultant Neonatal Paediatrician at Monash Children’s Hospital, said “It is a clinician scientist’s ultimate goal to be part of research that can be translated into future patient treatments.”
Original Article: Flicking the inflammation off-switch
More from: Hudson Institute of Medical Research | Monash University
The Latest on: Inflammation switch
- Red Sox notebook: Prospect Brayan Bello could switch places with Chris Sale after MLB debut on Wednesdayon July 5, 2022 at 8:19 pm
Manager Alex Cora wouldn’t say if he’s told Bello that he’ll be going back to the minors after his spot start but the writing is on the wall, especially with Chris Sale pitching in what ...
- Here’s What Happened When I Used a CBD Topical for Getting Tattooedon July 5, 2022 at 9:30 am
While the machinery and process have improved over the years, getting tattooed is still painful for the artist and customer alike. Penetrating through five sublayers of the epidermis, or 1/16 of an ...
- 7 Ways to Stop Dementia, Says Expertson July 3, 2022 at 3:45 am
While there's no cure for dementia, there are ways to help reduce the symptoms. Read on to ensure your health.
- Best cannabis skincare: CBD and hemp products for inflammation, acne and anti-ageingon June 30, 2022 at 6:40 pm
Both hemp and marijuana plants belong to the cannabis sativa species, while there are hundreds of cannabinoid compounds found in cannabis, including CBD. But it’s the non-psychoactive hemp and ...
- Turncoat T cells are at the core of multiple sclerosis and other inflammatory central nervous system disorderson June 30, 2022 at 6:10 am
Intriguing new research has pinpointed a special population of T cells—tissue-resident memory T cells—as key players in the development of chronic autoimmune disorders that affect the central nervous ...
- Long Covid: Nutritionist recommends best anti-inflammatory foods to help symptomson June 15, 2022 at 2:06 pm
“When an acute infection has been cleared, a well-functioning immune system will switch off the inflammatory messages so that body tissues can return to normal. “If this inflammatory response ...
- The Benefits Of Omega-3 Supplements, According To Expertson June 15, 2022 at 12:35 pm
Reduced inflammation can reduce your risk for related ... “One is to simply switch brands. A second solution is to switch to a non-fish based supplement. Another is to buy pills that come ...
- Researchers: Depression May Be a Physical Illness Linked to Inflammationon June 14, 2022 at 5:00 pm
Widespread inflammation, they posit ... In the case of chronic depression, the immune system may be failing to “switch off” after an illness or trauma, leading to persistent symptoms.
- Foot and ankle mobility: Exercises to do in bed or while seatedon June 10, 2022 at 11:46 am
Then, switch feet.4. Ankle rotationExtend one leg ... including Achilles tendinitis and plantar fasciitis, or inflammation of the sole tissue, according to research. Engaging your calf muscles ...
via Bing News
The Latest on: Inflammation switch
via Google News
Add Comment