Schematic illustration of the transdermal delivery of cells using cryomicroneedles.
A research team led by biomedical engineers at City University of Hong Kong (CityU) has developed a new generation of microneedle patches made of ice that melt after the pain-free delivery of drugs.
Experiments using this groundbreaking invention on mice with cancers have shown that the animals’ immune responses were much better than those seen in conventional vaccination methods. The technology paves the way for developing an easy-to-use cell therapy and other therapeutics against cancers and other diseases.
Made from a cryogenic solution, these icy microneedles are less than 1mm long and can deliver living mammalian cells into the skin. The device is like a skin patch and the microneedles can detach from the patch base, melt and then penetrate the skin.
The research is led by Dr Xu Chenjie, Associate Professor in the Department of Biomedical Engineering (BME), and the findings were published in Nature Biomedical Engineering under the title “Cryomicroneedles for Transdermal Cell Delivery”.
“Traditional cell therapy for skin disorders is invasive, painful, complicated, low-efficient, risks infection, and requires experienced professionals,” Dr Xu explained. “Our ready-to-use device can circumvent complex and redundant procedures during each drug administration. In addition, it can be stored for months in a refrigerator and is easily transported and deployed.”
The applications for this device are not limited to the delivery of cells. It can package, store, and deliver bioactive therapeutic agents such as proteins, peptides, mRNA, DNA, bacterial, and vaccines, and it can improve both the therapeutic efficacy and patient compliance during cell therapies.
As a proof-of-concept, the researchers explored cell-based cancer immunotherapy through the intradermal delivery of ovalbumin-pulsed dendritic cells. Experiments showed that vaccination using therapeutic cells through this technology elicited robust antigen-specific immune responses and provided strong protection against tumours in mice. These results were superior to the therapeutic outcomes of conventional vaccination methods. One of the start-up teams supported by the Seed Fund of HK Tech 300, CityU’s flagship innovation and entrepreneurship programme, is working on transferring the technology into product and to promote its application.
Dr Chang Hao, a former postdoc in CityU’s BME, is the first author of this study, and Dr Xu is the corresponding author. Other researchers include Professor Wang Dongan and Professor Shi Peng from BME. The research team collaborated with scientists from Nanyang Technological University and National University of Singapore.
A cryomicroneedle patch placed on the hand to demonstrate the melting of the needles on the skin.
Original Article: Painless drug delivery via melting ice microneedle patches
The Latest on: Microneedle patches
- A strategy to thermally stabilize microneedle vaccine technologyon December 2, 2022 at 9:51 am
Researchers in the Department of Biomedical Engineering—a shared department between the UConn Schools of Dental Medicine, Medicine, and Engineering—unlocked a new strategy using sugar molecules to ...
- Global CBD Patches Market To Surge Ahead At A CAGR Of 18.7% To End Up At A Market Size Of US$ 691.9 Million By 2033on December 1, 2022 at 3:18 am
Rockville, Nov. 30, 2022 (GLOBE NEWSWIRE) -- According to Fact.MR, a market research and competitive intelligence provider, the global CBD patches market is set to reach US$ 124.6 million in 2023 ...
- 17 Pimple Patches That Make Dealing With Acne a Breezeon November 30, 2022 at 11:31 am
However, pimple patches aren't a magic bullet and require some additional support—such as potent serums, full-coverage SPFs, and moisturizing moisturizers—to ensure all of their efforts aren't ...
- Drop What You're Doing and Update iOS, Android, and Windowson November 30, 2022 at 7:56 am
November saw the release of patches from the likes of Apple’s iOS, Google Chrome, Firefox, and Microsoft Windows to fix multiple security vulnerabilities. Some of these issues are pretty severe ...
- How to Get Ability Patch in Pokemon Scarlet and Violeton November 29, 2022 at 11:11 am
The Ability Patch is a useful item that players can use in Pokemon Scarlet and Violet to unlock the hidden ability on their Pokemon. If you're trying to maximize stats for breeding or battling ...
- Vegetation-free patches encourage ground-nesting wild beeson November 29, 2022 at 7:22 am
To test whether ground-nesting wild bees prefer to build their nests in vegetation-free areas, the research team removed the vegetation on three patches on each of the eight calcareous grasslands.
- 2023 Treasure Hunt medallion patches are now on saleon November 28, 2022 at 2:39 pm
New for 2023: Be the first to get the 2023 Pioneer Press Treasure Hunt medallion patch. This will be the first of many for years to come. We have a limited number of medallion patches for sale ...
- NYPD sergeant punished for wearing pro-Trump patches at Black Lives Matter proteston November 28, 2022 at 5:54 am
16. Martillo was caught on video wearing two patches, one with the Punisher skull logo with Trump-style hair, and a second with a similar image and the words, “Trump 2020″ and “Make ...
- Microneedle Patch Market Size 2022 Global Analysis Report by Top Companies, Trends, Growth Factors, Detail Business Development and Forecast to 2026on November 24, 2022 at 5:27 am
Global “Microneedle Patch Market” 2022 competitive landscape provides particulars and data information on key players, product types, application and geographical regions (North America ...
- The 8 Best Pimple Patcheson November 23, 2022 at 10:40 am
It’s so strange to think that we used to get by without pimple patches. Now, if you notice an angry zit developing, you pop on a pimple patch for a few hours and the sticker will suck the ...
via Bing News
The Latest on: Microneedle patches
[google_news title=”” keyword=”microneedle patches” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News