Home » Innovation Center of NanoMedicine » Smart nanomachines for cancer detection after surgery

Smart nanomachines for cancer detection after surgery

Left: Primary tumor or overt metastasis Center: Center: Pre-metastatic niche Right: Post-surgical wound

CREDIT: 2021 Innovation Center of NanoMedicine

Left: Primary tumor or overt metastasis Center: Center: Pre-metastatic niche Right: Post-surgical wound

CREDIT: 2021 Innovation Center of NanoMedicine


  • Matrix metalloproteinases (MMPs) is an enzyme required for cancer cells to metastasize/invade, and cancer cells with higher MMP activity have higher metastasis ability and progress quickly.

In this study, we created polymersomes (smart nanomachines) that act specifically in tissues that overproduce MMPs, prevent cancer metastasis, and developed a method to remove residual tumor tissue that could not be visually confirmed after surgery.

  • We simultaneously loaded the cell division inhibitor colchicine and the MMP inhibitor marimastat into MMPs-responsive polymersomes as an enzymatically transformable nanomachine designed to achieve transformation following dePEGylation by cleavage of the inserted substrate peptide by MMPs. The effect on malignant tumors with high MMPs activity was evaluated.
  • During transformation, nanomachines with exposed guanidine residues easily penetrate into cells, and at the same time, by releasing the contained drugs, it exerts an anti-cancer effect.
  • Evaluating drug uptake using HT1080 cells derived from human fibrosarcoma that overproduce MMPs, studying pharmacokinetic and nano-bio interaction using a confocal laser scanning biomicroscope and evaluating metastasis inhibitory effect using triple-negative breast cancer transplantation model, the results were published in Advanced Materials (IF = 30.849 in 2021).


Original Article: Creating smart nanomachines to detect highly invasive cancer after surgery and prevent recurrence – cancer metastasis and recurrence prevention

More from: Innovation Center of NanoMedicine | University of Science and Technology of China


The Latest on: Smart nanomachines

  • The Precision Upon Which Civilizations Are Built
    on June 28, 2022 at 5:00 pm

    The next step in modifying matter, because machining is only a modyfing matter mechanism. Will be “intelligent matter”, “programmable matter” , or “intelligent atoms”. A definition of ...

  • ETH News
    on June 27, 2022 at 5:01 pm

    The Swiss National Science Foundation has awarded Advanced Grants to make up for the loss of European support. Researchers at ETH Zurich did particularly well, with 6 of the 24 grants going to the ...

  • The best James Bond gadgets: essential pieces of kit from 007’s adventures
    on June 25, 2022 at 8:51 am

    The best James Bond gadgets: essential pieces of kit from 007’s adventures "Nobody does it better," sang Carly Simon in the theme to The Spy Who Loved Me, but 007 does get an awful lot of help ...

  • ETH News
    on June 23, 2022 at 5:00 pm

    Researchers at ETH Zurich have developed a wearable textile exomuscle that serves as an extra layer of muscles. They aim to use it to increase the upper body strength and endurance of people with ...

  • The Future of Medical Devices: 2025 A.D.
    on June 23, 2022 at 5:00 pm

    Just as we saw shape-memory alloys, plastic materials, and advanced fabrication technologies go from laboratories to manufacturing facilities, genetic treatments, tissue engineering, and nanomachines ...

  • Overview about intelligent drug delivery by biohybrid micro- and nanorobots
    on June 17, 2022 at 6:11 am

    The purpose of the medical microrobotics is to develop and deploy large numbers of micro/nanomachines to carry out diverse medical ... gives an overview of biohybrid micro- and nanorobots for smart ...

  • 3D Printing Turns Nanomachines into Human-Scale Workers
    on June 14, 2022 at 5:00 pm

    Now researchers have found a way to harness the power of nanomachines to work on a human scale, paving ways for potential breakthroughs in smart materials and devices. Using advanced 3D printing, ...

  • The physicochemical nature of colloidal motion waves among silver colloids
    on June 8, 2022 at 5:00 pm

    In a new report now published in Science Advances, Xi Chen and a team of researchers in smart materials, physics and optics at the Harbin Institute of Technology, and the Shanghai Jiao Tang ...

  • gray goo
    on August 16, 2020 at 9:37 am

    Eric Drexler, in which nanomachines were named "assemblers." An assembler is created from organic molecules and is designed to replicate itself. However, if something goes amiss, they could ...

  • A nano-hospital in every body
    on January 14, 2019 at 10:17 pm

    “You might have nanomachines made from organic compounds ... or Center of Open Innovation Network for Smart Health. COINS unites medical researchers, engineers and clinicians from five ...

via Bing News

The Latest on: Smart nanomachines

via Google News

Add Comment

Click here to post a comment

Your thoughtful comments are most welcome!

This site uses Akismet to reduce spam. Learn how your comment data is processed.