The Howard Hughes Medical Institute (HHMI) is a United States non-profit medical research organization based in Chevy Chase, Maryland.
Using genetically engineered bacteriophages to fight infection: Viruses that can infect and kill bacteria
Scientists have used an experimental therapy that relies on bacteria-infecting viruses collected, in part, through HHMI’s SEA-PHAGES program to fight a Mycobacterium infection in a 15-year-old girl. The patient, a 15-year-old girl, had come to London’s Great Ormond Street Hospital for a double lung transplant. It was the summer of 2017, and her lungs were struggling to
New hope for neurodegenerative brain disorders
DGIST’s research Team has clarified the fundamentals of coiled toxin protein which causes neurodegenerative brain disorders A research team led by Professor Sung Bae Lee of Brain and Cognitive Sciences and Professor Daehee Hwang of New Biology (Vice-head of the Plant Age and Life Research Group, IBS) has identified the early neuropathology mechanism of structural
Using genomics and gene editing rapidly bring groundcherries toward domestication
By combining genomics and gene editing, researchers have figured out how to rapidly bring a plant known as the groundcherry toward domestication. Strawberries, blueberries, blackberries, raspberries, and… groundcherries? A little-known fruit about the size of a marble could become agriculture’s next big berry crop. To prepare the groundcherry (Physalis pruinosa) for mainstream farming, Howard Hughes Medical Institute
Easy-to-use technology that simultaneously monitors neural activity at hundreds of different sites within the brain
Neuropixels probes represent a significant advance in measurement technology and will allow for the most precise understanding yet of how large networks of nerve cells coordinate to give rise to behavior and cognition. Neuroscientists who want to follow the nervous system’s cellular conversations will soon have access to easy-to-use technology that simultaneously monitors neural activity
A process that could one day enable precise DNA surgery to correct mutations that cause human diseases
A new type of DNA editing enzyme, developed in HHMI Investigator David Liu’s lab, lets scientists directly and permanently change single base pairs of DNA from A•T to G•C. The process could one day enable precise DNA surgery to correct mutations that cause human diseases. DNA editing just got a sharp, new pencil. Researchers have
AI saves 3,800 years work building the most comprehensive neural maps of behavior yet created (fly)
Scientists at HHMI’s Janelia Research Campus created comprehensive brain maps linking different groups of neurons to specific behaviors, using a machine-learning program that annotated more than 225 days of videos of flies – a feat that would have taken humans some 3,800 years. A smart computer program named JAABA has helped scientists create a brain-wide
IsoView Microscope helps scientists see the big picture
High-speed microscope images entire living organisms at high resolution A new microscope developed at the Howard Hughes Medical Institute’s Janelia Research Campus is giving scientists a clearer, more comprehensive view of biological processes as they unfold in living animals. The microscope produces images of entire organisms, such as a zebrafish or fruit fly embryo, with
Another Milestone in Hybrid Artificial Photosynthesis
Berkeley Lab Researchers Use Solar Energy and Renewable Hydrogen to Produce Methane A team of researchers at the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) developing a bioinorganic hybrid approach to artificial photosynthesis have achieved another milestone. Having generated quite a buzz with their hybrid system of semiconducting nanowires and bacteria
NTU scientists discover new treatment for dementia
Pushing new frontiers in dementia research, Nanyang Technological University, Singapore (NTU Singapore) scientists have found a new way to treat dementia by sending electrical impulses to specific areas of the brain to enhance the growth of new brain cells. Known as deep brain stimulation, it is a therapeutic procedure that is already used in some
Molecule-making machine simplifies complex chemistry
A new molecule-making machine could do for chemistry what 3-D printing did for engineering: Make it fast, flexible and accessible to anyone. Chemists at the University of Illinois, led by chemistry professor and medical doctor Martin D. Burke, built the machine to assemble complex small molecules at the click of a mouse, like a 3-D
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